Figure 5 Correlation of artemin with neural alterations in chronic pancreatitis (n = 66). After PGP9.5 staining, the whole chronic pancreatitis tissues were scanned and the marked nerves were counted using the software for Zeiss KS300, Zeiss AxioCam HR. Nerves in chronic pancreatitis increased (A) in total nerve number (neural sprouting) and (B) in the total area of nerves (neural hypertrophy) (*p<0.001) compared with the normal pancreas (NP). (C) Spearman Rho correlation revealed a positive correlation between artemin mRNA expression and neural density (p<0.002) as well as neural hypertrophy (p<0.006) (D) in chronic pancreatitis (CP). Glial derived neurotrophic factor family receptor (GFR)α3 was also positively correlated with neural hypertrophy (p<0.005) (E) but did not show a significant correlation with neural density (F).