Table 1 Secretion profile of mutant retinoschisin.

Mutations	Base changes	Amino acid changes	Secretion	Mutation affects conserved residue	Discoidin domain
L12H*	GGG‐GAG	Leu‐His	−	−	No
C59S*	TGT‐AGT	Cys‐Ser	+	−	No
G70S*	TGT‐AGT	Gly‐Ser	−	+	Yes
Y89C	TAT‐TGT	Tyr‐Cys	−	−	Yes
W92C	TGG‐TGC	Trp‐Cys	−	+	Yes
W96R	TGG‐CGG	Trp‐Arg	−	+	Yes
R102W*	CGG‐TGG	Arg‐Trp	−	+	Yes
N104K	AAC‐AAG	Asn‐Lys	−	+	Yes
F108C	TTT‐TGT	Phe‐Cys	+	−	Yes
G109R*	GGG‐CGG	Gly‐Arg	−	−	Yes
G109E	GGG‐GAG	Gly‐Glu	−	−	Yes
C110Y	TGT‐TAT	Cys‐Tyr	−	−	Yes
W112C	TGG‐TGT	Trp‐Cys	−	+	Yes
L113F	CTC‐TTC	Leu‐Phe	−	−	Yes
R141H	CGC‐CAC	Arg‐His	+	−	Yes
R141G*	CGC‐GGC	Arg‐Gly	+	−	Yes
C142W*	TGT‐TGG	Cys‐Trp	−	+	Yes
D143V	GAC‐GTC	Asp‐Val	−	−	Yes
R182C	CGC‐TGC	Arg‐Cys	+	−	Yes
H207Q	CAC‐CAG	His‐Gln	+	−	Yes
R209H	CGC‐CAC	Arg‐His	+	−	Yes
R213W	CGG‐TGG	Arg‐Trp	−	+	Yes
C219G	TGC‐GGC	Cys‐Gly	+	+	Yes
C223R	TGT‐CGT	Cys‐Arg	+	−	No

*Published previously.¹⁵