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. 2000 May 9;97(11):6138–6143. doi: 10.1073/pnas.110126897

Figure 3.

Figure 3

Inhibition of solubilized γ-secretase activity by L-685,458 and pepstatin. (A) Structure of L-685,458. (B) Evaluation of the inhibitory potencies of L-685,458 and pepstatin on solubilized γ-secretase activity. CT100Flag was added to solubilized γ-secretase containing the indicated concentrations of L-685,458 or pepstatin and incubated for 60 min. The ECL assay was used to detect M-Aβ40 (●) and M-Aβ42 (○) in the L-685,458-treated samples and M-Aβ40 (■) and M-Aβ42 (□) in the pepstatin-treated samples. The data are expressed as % of that observed in the absence of either L-685,458 or pepstatin. Shown are the mean values of two and five independent experiments with L-685,458 and pepstatin, respectively.