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. 2006 Jul;90(7):819–822. doi: 10.1136/bjo.2005.086850

Table 4 Summary of complications of MMC in studies utilising MMC for treating ocular surface malignancy.

Study Ocular surface malignancy No of patients in study Regimens of MMC Complications of MMC No of patients affected
Frucht‐Pery et al9 Corneal intraepithelial neoplasia 3 0.02% MMC four times daily for 10–22 days Conjuntival hyperaemiaOcular pain 32
Blepharospasm 1
Frucht‐Pery et al1 Conjunctival‐corneal intraepithelial neoplasia 17 0.02–0.04% MMC four times daily for 7–28 days Ocular painConjunctival hyperaemia 28
blepharospasm 1
Allergy (probable) 2
Heigle et al3 Recurrent conjunctival epithelial neoplasia 3 0.04% three times daily for 3 weeks, 1 week on/1 week off Corneal oedema and epithelial toxicity 1
Wilson et al4 Conjunctival and corneal epithelial dysplasia and neoplasia 7 0.04% MMC four times daily for 4–21 days, in alternate weeks Conjunctival inflammationOcular painPunctate epithelial keratopathy 572
Finger et al6 Conjunctival melanoma and PAM with atypia 10 0.04% MMC qid for 28 days (4) and 7 days (6) KeratoconjunctivitisCorneal haze 101
Demirci et al7 Conjunctival malignant melanoma and PAM with atypia 12 0.04% four times daily for 28 days (7) Keratoconjunctivitis 12
0.04% four times daily for 7 days (5) Focal corneal haze 1
Daniell et al2 Corneal conjunctival intraepithelial neoplasia 20 0.02–0.04% MMC four times daily for 1–5 weeks, 1 week on/1 week off Epithelial toxicityContact dermatitisDisciform keratitis 1021
Membranous conjunctivitis 1
Shields et al10 Diffuse conjunctival corneal squamous cell carcinoma 10 0.04% MMC four times daily for 1–4 weeks, 1 week on/1 week off Conjunctival erythemaConjunctival irritationConjunctival chemosis 632
Punctate keratopathy 1
Shields et al8 Sebaceous gland carcinoma with conjunctival pagetoid spread 4 0.04% MMC four times daily for 1–4 weeks, 1 week on/1 week off Ocular painConjunctival irritationConjunctival injection 134
Recurrent corneal abrasion 1
Peripheral corneal pannus 1
Sacu et al12 Conjunctival malignant melanoma 1 0.04% MMC four times daily for 8 weeks, two 28 days courses, separated by 1 month Intumescent cataract 1
Billing et al13 Corneal epithelial dysplasia 1 0.04% MMC four times daily for 2 weeks, 1 week on/1 week off Punctal canalicular stenosis 1
Dudney et al11 Conjunctival corneal intraepithelial neoplasia 1 0.04% MMC four times daily for 5 weeks, five 1 week courses Recurrent non‐healing corneal epithelial defects/limbal stem cell deficiency 1
Kopp et al14 MM, PAM, SCC 14 0.04% MMC four times daily for 2–18 weeks, one to six 2 week courses Punctal canalicular stenosis 6