Table 3 Published cases with primary lacrimal sac lymphoma.
| Case | Diagnosis | Sex | Age | Symptoms | Stage* at diagnosis | Treatment | Follow up (months) | Authors | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | DLBCL | F | 70 | Epiphora, swelling | I | RT 50 Gy + CHOP × 1 | CR (26) | Nakamura et al15 | |
| 2 | DLBCL angiotropic | F | 87 | Epiphora, swelling, dacryocystitis | I | Excision | CR (24) | O'Connor et al19 | |
| 3 | DLBCL | M | 21 | Bloody epiphora, swelling | I | CHOP × 8 | CR (7) | Saccogna et al17 | |
| 4 | DLBCL | F | 72 | Epiphora, swelling, dacryocystitis | De Palma et al20 | ||||
| 5–6 | DLBCL | NA | NA | NA | I | NA | NA | McKelvie et al13 | |
| 7 | DLBCL | F | 74 | Epiphora, swelling, proptosis | I | RT + CHOP × 3 | Relapse LN (24) | Parmar and Rose16 | |
| 8 | DLBCL | F | 63 | Epiphora, swelling | I | RT + CT | CR (24) | Parmar and Rose16 | |
| 9 | MALT | F | 50 | Epiphora, swelling | I | RT | CR (16) | Parmar and Rose16 | |
| 10 | MALT | F | 56 | Epiphora, swelling | I | RT | CR (46) | Parmar and Rose16 | |
| 11 | MALT | F | 81 | Epiphora, swelling | I | Chlorambucil | CR (36) | Parmar and Rose16 | |
| 12 | MALT | M | 10 | Epiphora, swelling | I | CHOP × 2 | CR (30) | Schefler et al18 | |
| 13 | MALT | F | 55 | NA | NA | NA | Alive (98) | Takada et al21 | |
| 14–17 | MALT | NA | NA | NA | NA | NA | NA | Anderson et al8 | |
| 18 | Plasmacytoma | NA | NA | NA | NA | NA | NA | Anderson et al8 | |
| 19 | NK/T | F | 51 | Swelling | II† | CHOP × 6 | DOD (9) | Mori et al14 |
CHOP, cyclophosphamide + hydroxydoxorubicine + oncovine + prednisone; CR, complete remission; DLBCL, diffuse large B cell lymphoma; DOD, dead of disease; F, female; Gy, Gray; LN, lymph nodes; M, male; MALT, extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue; NK/T, extranodal NK/T cell lymphoma; NA, not available; RT, radiation therapy.
*Ann Arbor stage.
†At presentation the lymphoma was localised to the lacrimal sac, 4 weeks later it extended into the ethmoidal sinus.