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. 2000 May 23;97(11):6144–6149. doi: 10.1073/pnas.97.11.6144

Figure 3.

Figure 3

Expression patterns of molecular markers and glutamate receptors in different classes of neocortical neurons. The percentage of neurons expressing a given mRNA is represented by a gray scale, as indicated on the bottom of the figure. Pyramidal cells (Pyr) did not express GADs in contrast to the other classes of neurons. FS cells consistently expressed PV and NPY. The majority of RSNP-SS cells expressed SS, whereas most of RSNP-VIP and IS cells expressed VIP. The distribution of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits revealed that the five classes of neurons frequently expressed GluR1 and GluR2. GluR3 was very rare in RSNP-VIP and IS. Pyramidal cells lacked GluR4 subunits. The distribution of kainate receptor subunits showed that KA2 subunit was the most frequently observed subunit. GluR5 subunit was not expressed in pyramidal cells. Distribution of N-methyl-d-aspartate (NMDA) subunits indicated that NR2A and NR2B were detected frequently in the five classes of cells. NR2D was more frequent in interneurons than in pyramidal cells. The distribution of mGluRs showed that mGluR1 was frequent in fusiform cells. mGluR5 was the most frequently expressed mGluR. Group III mGluRs were rare in FS cells.