Table 1.
Electrophysiological properties of five types of cortical neurons
| Electrophysiological parameters | Pyr (n = 9) | FS (n = 16) | RSNP-SS (n = 12) | RSNP-VIP (n = 32) | IS (n = 16) |
|---|---|---|---|---|---|
| (i) Input resistance, MΩ | 247 ± 88 | 203 ± 85 | 298 ± 108 | 430 ± 139 | 395 ± 157 |
| FS, Pyr, RSNP-SS ≪ IS, RSNP-VIP | |||||
| (ii) First spike amplitude, mV | 89.9 ± 10.2 | 80.8 ± 9.6 | 88.1 ± 6.0 | 91.6 ± 6.6 | 83.4 ± 10.0 |
| FS, IS < Pyr, RSNP-SS, RSNP-VIP | |||||
| (iii) Second spike amplitude, mV | 80.3 ± 11.4 | 76.6 ± 8.6 | 85.8 ± 5.6 | 84.6 ± 6.5 | 71.2 ± 10.2 |
| FS, IS ≪ RSNP-VIP, RSNP-SS | |||||
| (iv) Amplitude reduction, % | 10.7 ± 7.7 | 5.0 ± 3.5 | 2.5 ± 3.4 | 7.5 ± 6.1 | 14.5 ± 8.1 |
| RSNP-SS ≪ RSNP-VIP, Pyr, IS | |||||
| (v) First spike duration, ms | 1.27 ± 0.33 | 0.43 ± 0.12 | 0.48 ± 0.15 | 0.69 ± 0.23 | 0.54 ± 0.23 |
| FS, RSNP-SS, IS ≪ RSNP-VIP ≪ Pyr | |||||
| (vi) Second spike duration, ms | 2.01 ± 0.93 | 0.43 ± 0.15 | 0.51 ± 0.15 | 0.78 ± 0.31 | 0.61 ± 0.26 |
| FS, RSNP-SS ≪ RSNP-VIP ≪ Pyr and IS ≪ Pyr | |||||
| (vii) Duration increase, % | 58.3 ± 48.2 | −2.4 ± 12.7 | 6.6 ± 10.1 | 10.0 ± 9.7 | 15.0 ± 15.6 |
| FS, RSNP-SS, RSNP-VIP, IS ≪ Pyr and FS ≪ RSNP-VIP, IS | |||||
| (viii) First spike AHP, mV | −2.6 ± 2.6 | −21.5 ± 3.1 | −12.2 ± 4.8 | −13.6 ± 4.0 | −11.5 ± 3.5 |
| FS < RSNP-VIP, RSNP-SS, IS ≪ Pyr | |||||
| (ix) Second spike AHP, mV | −8.2 ± 4.4 | −22.8 ± 2.5 | −11.8 ± 4.2 | −14.2 ± 4.3 | −14.4 ± 4.2 |
| FS ≪ IS, RSNP-VIP ≪ Pyr and FS < RSNP-SS | |||||
| (x) Early adaptation, % | 77.1 ± 7.9 | 19.6 ± 18.0 | 58.3 ± 18.0 | 61.1 ± 15.4 | 85.4 ± 14.5 |
| FS < RSNP-SS, RSNP-VIP ≪ Pyr, IS | |||||
| (xi) Late adaptation, % | 4.2 ± 2.3 | 7.3 ± 8.7 | 10.8 ± 9.4 | 8.8 ± 7.0 | 8.1 ± 12.8 |
| n.s. | |||||
| (xii) Accommodative hump, mV | 12.0 ± 4.0 | 3.0 ± 3.7 | 1.8 ± 2.8 | 7.1 ± 4.8 | 3.2 ± 3.8 |
| FS, RSNP-SS, IS ≪ RSNP-VIP ≪ Pyr | |||||
| (xiii) Minimal frequency, Hz | 18.5 ± 5.4 | 57.4 ± 24.2 | 28.0 ± 8.6 | 27.4 ± 12.3 | 14.7 ± 22.3 |
| IS, Pyr < RSNP-SS, RSNP-VIP ≪ FS | |||||
| (xiv) Time for minimal frequency, ms | 774 ± 66 | 749 ± 128 | 735 ± 113 | 726 ± 112 | 464 ± 140 |
| IS ≪ Pyr, FS, RSNP-SS, RSNP-VIP | |||||
Values are means ± SD. n, number of cells; Pyr, pyramidal cells; <, significantly smaller with P = 0.05; ≪, significantly smaller with P = 0.01; n.s., not statistically different. Statistically significant differences were determined by using the Mann–Whitney U test. Electrophysiological parameters were measured as described in Materials and Methods.