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. 2007 May 1;117(5):1167–1174. doi: 10.1172/JCI31202

Figure 1. The not enough of a good thing paradigm.

Figure 1

APCs (especially DCs) capture antigen from tumor cells. Antigen-loaded APCs then prime naive T cells to become antitumor CTLs through soluble mediators such as IL-12 and/or cosignaling molecules such as CD80 or CD86. Failure to elicit protective immunity is seen as a lack of sufficient quantity or quality of 1 of these events (indicated in red text). This model predicts that augmenting numbers or quality of a specific component will suffice as a clinical strategy.