Figure 1.
Survival and weight loss after vaccinia virus challenge. Six mice/group were vaccinated with vaccinia virus by scarification (VV-vac) or with vaccine formulations containing A33, B5, L1 along with CpG and alum (ABL/CpG/alum), A33, B5, L1, A27 along with CpG and alum (ABLA/CpG/alum) or A33, B5, A27 along with CpG and alum (ABA/CpG/alum). Control groups included unvaccinated naïve mice (Control), CpG and alum (CpG/alum), and the 4-proteins and alum (ABLA/alum). Three weeks after the boost vaccination, groups were challenged intranasally with ~15LD50 (~6 x 106 pfu) of vaccinia virus (strain WR). A. Survival curve. B. Weight loss during the course of infection.