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. Author manuscript; available in PMC: 2008 Feb 26.
Published in final edited form as: Mol Cell Endocrinol. 2007 Jan 16;265-266:77–82. doi: 10.1016/j.mce.2006.12.007

Table 1.

Specific activities for the reduction of 5α-DHT to 3α-diol and 3β-diol catalyzed by human AKR1C isoforms

Specific Activity [nmoles min−1mg−1]1
Product AKR1C1 AKR1C2 AKR1C3 AKR1C4
3α-Diol 2.8 75.6 2.7 102.0
3β-Diol 12.4 4.4 2.0 29.8
1

Assayed with 40 μM 5α-DHT plus 180 μM NADPH at 37°C. From Steckelbroeck et al. 2004.