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Activation of VR1 by products of LOs in an inside-out membrane patch of a VR1-transfected HEK 293 cell. (Inset) Current traces in an expanded time scale (Left) and current-voltage relationship of channels (Right) activated by 12-(S)-HPETE in HEK 293 cells transfected with VR1. 15-(S)-HETE and 15-(S)-HPETE are also capable of activating VR1 expressed in HEK 293 cells (lower traces).
