Figure 5.

Effects of various lipids other than products of LOs on i_cap in cultured dorsal root ganglion neurons. (A) PGE₂ fails to activate i_cap in inside-out membrane patch. (B) Current response of i_cap to AA. (C) Block by baicalein, a 12-LO inhibitor, of the i_cap activated by AA. (D) Relative channel activities of the various lipids expressed as normalized to the channel activity (NP_o) obtained with 10 μM 12-(S)-HPETE. DHA, docosahexaenoic acid; DHL, dihomo-γ-linolenic acid; SAG, 1-stearyl-2-arachidonyl-sn-glycerol. Numbers above the bars represent the number of experiments. Relative channel activities of the lipids are significantly (P < 0.001) different from the channel activity (NP_o) of 10 μM 12-(S)-HPETE.