Figure 3 LRP5 mutation c1648G>A identified in recessive FEVR family. (A) Sequence trace of mutation in IV:1 (mutant), III:1 (heterozygote), and control individual (wild type). (B) Protein sequence alignment of human LRP5 with homologues from other species: Pan troglodytes (chimp), Canis familiaris (dog), Mus musculus (mouse), Gallus gallus (chick), Xenopus laevis (toad), Tetraodon nigroviridis (fish), Anopheles gambiae str (mosquito), and Drosophila melanogaster (fly). Only 20 amino acid residues surrounding each mutation are shown. Conserved amino acid residues are highlighted. G550R affects a fully conserved amino acid.