Table 1 Summated percentage adherence of wild‐type and Sorsby's fundus dystrophy‐mutant tissue inhibitor of metalloproteinase‐3s to selected components of Bruch's membrane.
| Matrix component | Percentage control binding | p Values relative to control |
|---|---|---|
| Control (well‐base plastic) | 100 (3.2) | — |
| Elastin (acid prepared) | 115 (13.1) | 0.049 |
| Elastin (KOH prepared) | 98 (4.5) | 0.510 |
| Type‐I collagen | 48 (3.2) | <0.001 |
| Type‐IV collagen | 48 (4.2) | <0.001 |
| Fibronectin | 72 (4.7) | <0.001 |
| Laminin | 108 (7.2) | 0.070 |
| Chondroitin sulphate A | 61.5 (9.4) | 0.001 |
| Chondroitin sulphate B | 67.5 (8.2) | 0.001 |
| Chondroitin sulphate C | 68.0 (9.9) | 0.002 |
| Heparin sulphate | 80.4 (10.4) | 0.015 |