Table 3 Summary of ocular findings observed by the examining physician in 2‐year‐old randomised children who had bilateral high‐risk, prethreshold retinopathy of prematurity.
| Variables | Sample size | % Present* | % Unable to assess | Discordant pairs† | p Value‡ | ||
|---|---|---|---|---|---|---|---|
| Earlier‐treated eye | Conventionally managed eye | Earlier‐treated eye | Conventionally managed eye | ||||
| Corneal opacification | 269 | 1.5 | 2.6 | 0 | 0.7 | 6/3 | 0.51 |
| Amblyopia | 269 | 5.9 | 10.8 | 0 | 0 | 27/14 | 0.06 |
| Anterior segment | |||||||
| Synechiae | 269 | 1.9 | 1.9 | 1.5 | 2.2 | 4/4 | 1.00 |
| Cataract or aphakia | 269 | 4.1 | 6.0 | 0.7 | 1.1 | 12/7 | 0.36 |
| Glaucoma | 269 | 0.7 | 1.5 | 0.0 | 0.7 | 3/1 | 0.63 |
| Extensive vitreous membranes/org | 269 | 2.6 | 4.2 | 0.4 | 1.5 | 9/5 | 0.42 |
| Fundus | |||||||
| Optic nerve‐pallor (part/severe) | 269 | 7.4 | 9.3 | 4.8 | 8.2 | 4/2 | 0.69 |
| Optic nerve cup:disc ratio ⩾0.5 | 269 | 7.8 | 10.1 | 5.2 | 8.2 | 3/0 | 0.25 |
| Straightened vessels in zone I | 269 | 17.9 | 18.1 | 4.5 | 7.4 | 18/12 | 0.36 |
| Macular ectopia | 269 | 5.4 | 4.8 | 4.1 | 7.4 | 7/6 | 1.00 |
| Foveal pigmentation disturbance | 269 | 5.4 | 5.6 | 4.5 | 7.8 | 4/4 | 1.00 |
| Retinal fold | 269 | 2.3 | 3.2 | 3.0 | 5.9 | 7/3 | 0.34 |
| Retrolental membrane | 269 | 2.6 | 3.4 | 1.5 | 3.0 | 7/4 | 0.55 |
| Retinal breaks or tears (periphery) | 269 | 0.4 | 0.4 | 4.1 | 8.2 | 0/1 | 1.00 |
| Pre‐retinal membranes (periphery) | 269 | 4.2 | 5.6 | 3.3 | 7.1 | 7/4 | 0.55 |
| Detachment or retinoschisis | 269 | 3.8 | 6.2 | 2.2 | 4.1 | 11/5 | 0.21 |
*Percent of those that were able to determine.
†Condition absent or normal in treated eye but not in control eye, or condition present or abnormal in treated eye but not in control eye.
‡p Values calculated using binomial probability distribution.