Table 1 Mitochondrial mutation, haplogroup and phenotype of OPTN Met98Lys carriers from pedigrees with Leber's hereditary optic neuropathy.

Pedigree	mtDNA mutation	mtDNA haplogroup	Age at most recent examination (years)	Sex	Manifesting LOV	Age at LOV (years)
Vic2	14484T→C (heteroplasmy)	J	19	F	Yes	6
Vic2	14484T→C (heteroplasmy)	J	50	F	Yes	14
Vic2	14484T→C (Heteroplasmy)	J	26	F	Yes	17
Vic19	11778G→A	B	22	M	Yes	24
Qld1	11778G→A	T	41	M	Yes	28
Tas1	11778G→A	H	45	M	No
Tas1	11778G→A	H	47	F	No
Tas1	11778G→A	H	21	M	No
Vic5	11778G→A	K	35	F	No
Vic5	11778G→A	K	62	F	No
Vic5	11778G→A	K	35	F	No
Vic6	11778G→A	H	48	F	No
Vic7	11778G→A	I	24	M	No
WA3	11778G→A	I	30	M	No

F, female; LOV, loss of vision; M, male; mtDNA, mitochondrial DNA.