Table 3 Phenotypic breakdown of patients with primary open‐angle glaucoma with and without the OPTN Met98Lys variant.
n | Mean (SD) age at examination | p Value | Mean (SD) age at diagnosis | p Value | Mean (SD) GIST severity score | p Value | Mean (SD) maximum IOP | p Value | Mean (SD) maximum CDR | p Value | |
---|---|---|---|---|---|---|---|---|---|---|---|
POAG without Met98Lys | 470 | 72.5 (10.9) | 0.49 | 62.8 (12.1) | 0.24 | 0.85 (0.11) | 0.27 | 24.0 (8.3) | 0.07 | 0.78 (0.16) | 0.76 |
POAG with Met98Lys | 28 | 73.9 (8.9) | 65.7±10.1 | 0.83 (0.12) | 20.9 (4.4) | 0.77 (0.14) | |||||
HTG without Met98Lys | 354 | 72.0 (11.06) | 0.55 | 61.9±12.2 | 0.74 | 0.86 (0.11) | 0.28 | 26.1 (8.3) | 0.71 | 0.77 (0.17) | 0.66 |
HTG with Met98Lys | 16 | 71.6 (7.1) | 63.7±7.7 | 0.83 (0.13) | 24.4 (3.4) | 0.76 (0.16) | |||||
NTG without Met98Lys | 116 | 74.2 (10.5) | 0.22 | 65.4±11.3 | 0.30 | 0.83 (0.10) | 0.91 | 16.9 (2.7) | 0.78 | 0.83 (0.12) | 0.14 |
NTG with Met98Lys | 12 | 77.1 (10.5) | 68.1 (12.3) | 0.83 (0.10) | 17.3 (1.4) | 0.79 (0.10) | |||||
Overall (POAG)* | 498 | 72.6 (10.8) | 62.9 (12.0) | 0.85 (0.11) | 23.8 (8.2) | 0.78 (0.16) |
CDR, worst eye cup:disc ratio; GIST, Glaucoma Inheritance Study in Tasmania; HTG, high‐tension glaucoma; IOP, intraocular pressure; NTG, normal‐tension glaucoma; POAG, primary open‐angle glaucoma;.
*Excluding myocilin mutation carriers.