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. 2006 Aug 2;90(11):1420–1424. doi: 10.1136/bjo.2006.099333

Table 3 Phenotypic breakdown of patients with primary open‐angle glaucoma with and without the OPTN Met98Lys variant.

n Mean (SD) age at examination p Value Mean (SD) age at diagnosis p Value Mean (SD) GIST severity score p Value Mean (SD) maximum IOP p Value Mean (SD) maximum CDR p Value
POAG without Met98Lys 470 72.5 (10.9) 0.49 62.8 (12.1) 0.24 0.85 (0.11) 0.27 24.0 (8.3) 0.07 0.78 (0.16) 0.76
POAG with Met98Lys 28 73.9 (8.9) 65.7±10.1 0.83 (0.12) 20.9 (4.4) 0.77 (0.14)
HTG without Met98Lys 354 72.0 (11.06) 0.55 61.9±12.2 0.74 0.86 (0.11) 0.28 26.1 (8.3) 0.71 0.77 (0.17) 0.66
HTG with Met98Lys 16 71.6 (7.1) 63.7±7.7 0.83 (0.13) 24.4 (3.4) 0.76 (0.16)
NTG without Met98Lys 116 74.2 (10.5) 0.22 65.4±11.3 0.30 0.83 (0.10) 0.91 16.9 (2.7) 0.78 0.83 (0.12) 0.14
NTG with Met98Lys 12 77.1 (10.5) 68.1 (12.3) 0.83 (0.10) 17.3 (1.4) 0.79 (0.10)
Overall (POAG)* 498 72.6 (10.8) 62.9 (12.0) 0.85 (0.11) 23.8 (8.2) 0.78 (0.16)

CDR, worst eye cup:disc ratio; GIST, Glaucoma Inheritance Study in Tasmania; HTG, high‐tension glaucoma; IOP, intraocular pressure; NTG, normal‐tension glaucoma; POAG, primary open‐angle glaucoma;.

*Excluding myocilin mutation carriers.