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Abrupt increments in LH concentrations (mean ± SD) elicited in response to lateral i.c.v. injection of 100 or 300 μg ( and ●, respectively) of the NPY Y1 receptor antagonist, 1229U91, at time 0 (arrowhead) in four juvenile monkeys with pituitaries sensitized to GnRH. Open data points show response to vehicle alone. The LH concentrations at 30 min after both doses of the Y1 antagonist were significantly different from vehicle.
