Figure 2.

Effect of GluR inhibitors on granule cell survival. Cultured neurons were treated for 24 h with vehicle (C), 10 μM CNQX, or 10 μM AP-5, in the presence or in the absence of 60 nM GROβ, in 5 mM K⁺-containing medium, as described in the legend to Fig. 1. Data are expressed as in Fig. 1 and are the mean ± SEM of at least six independent experiments. For statistic analysis, each group of cells was compared with the corresponding control: C vs GROβ; CNQX vs CNQX + GROβ; AP-5 vs AP-5 + GROβ. Student's t test: *, P < 0.001.