Skip to main content
. Author manuscript; available in PMC: 2007 Apr 27.
Published in final edited form as: J Mol Biol. 2006 Nov 10;366(1):307–315. doi: 10.1016/j.jmb.2006.11.017

Figure 1.

Figure 1

C2-WW-HECTc architecture. (a) Schematic architecture diagram from CDART. (b) Rearrangement tree for architectures containing the C2, WW, or HECTc domains and no other domains. Architectures shown here include C2-WW-HECTc (red), C2-WW (yellow), WW-HECTc (blue), WW-C2 (light blue), C2 (purple), WW (orange), and HECTc (green). The presence of each architecture in each species is indicated at the right. Each line of boxes on the tree corresponds to a potential rearrangement event that produces a new architecture at the closest labeled node. C2, WW, and HECTc single-domain architectures appear in Eukaryota as rearrangement class New Domain. C2-WW-HECTc appears at the Fungi/Metazoa node as a fusion of three architectures. The emergence of WW-HECTc and C2-WW can be attributed to the fission of C2-WW-HECTc or fusion of the respective one-domain architectures; the potential solutions differ for each of their new occurrences. The C2 and WW domains also appear in the other order, as WW-C2 architecture, which comes about through the respective fusions.