. Author manuscript; available in PMC: 2007 Apr 27.

Published in final edited form as: J Mol Biol. 2006 Nov 10;366(1):307–315. doi: 10.1016/j.jmb.2006.11.017

Table 4.

List of architectures that evolve into the largest number of children architectures (actual targets)

Domain/architecture name	Targets
ATP-binding site	260
Protein kinases	221
Tar and SH3 signal transduction, tropomyosin, pre-folding, and more	177
Ankyrin	141
Tetratricopeptide repeat domain	132
PH domain	124
REC signal receiver domain	115
RING-finger domain	112
WD40 domain	107
SH3 domain	104
Signal transduction histidine kinase	104