Table 1.
Strain | Gender | Mice # | Preneoplastic foci (%) | Adenoma | HCC | Mixed HCC | Total tumor incidence |
---|---|---|---|---|---|---|---|
WT | Male | 16 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
Female | 16 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
Total | 32 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
Fxr-null | Male | 31 | 19 (61)** | 10 (32)* | 2 (6.5) | 3 (9.7) | 10 (32)* |
Female | 22 | 15 (68)** | 9 (41)* | 1 (4.5) | 2 (9.1) | 10 (45)** | |
Total | 53 | 34 (64)** | 19 (36)** | 3 (5.7) | 5 (9.4) | 20 (38)** |
HCC; Hepatocellular carcinoma
P<0.05 compared with different genotype
P<0.05 compared with different genotype
No difference was seen among the different genders