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. Author manuscript; available in PMC: 2008 Jan 5.
Published in final edited form as: Neuroscience. 2006 Oct 19;144(1):247–262. doi: 10.1016/j.neuroscience.2006.08.078

Figure 7.

Figure 7

Continuous morphine via a mini osmotic pump age-dependently alters thermal nociception in infant and young rats. Pumps or morphine pellets were implanted on experimental day 1 and administered continuous morphine for 72 hours. Continuous morphine via mini osmotic pump produces tolerance in both infant and young rats. In contrast to mechanical thresholds, discontinuation of morphine does not alter thermal latencies at either age. Similarly, tolerance was observed in young rats implanted with a morphine pellet. A decrease in thermal latency was seen at 24 hours post-pellet removal in the young rats. Data is average ± SEM (n=5−6/group). αp<0.05 compared to time matched saline exposed animals, or time matched incision (no pump) controls. *p<0.05 compared to time matched incision (no pellet) controls.