Table 2.
Nephric duct and ureteric bud phenotypes in e11.5/12.5 Gata3+/z, Gata3z/z:Tg and Gata3z/z embryos
| Genotype | Complete ND | Shortened ND | ND on BW | No ND | Accessory UB | Separate “floating” UB | No UB |
|---|---|---|---|---|---|---|---|
| Gata3+/z | 21/21 (B)* | 2/21 | |||||
| TgHi:Gata3z/z | 12/12 (B) | 1/12** | |||||
| TgInt:Gata3z/z | 4/8 (B) | 1/8 (B)
1/8 (U) |
1/8 (U) | 1/8 | 1/8 (B)
1/8 (U) |
1/8 | |
| TgLo:Gata3z/z | 1/5 (B)
2/5 (U) |
4/5 (U) | 2/5 (U) | 5/5 | |||
| Gata3z/z | 1/13 (U) | 1/13 (U) | 11/13 (B)
2/13 (U) |
13/1
3 |
TgHi, H14 and H3; TgInt, G6 and H12; TgLo, B6. Complete ND = nephric duct (ND) fully extended beyond the normal ureteric budding site; Shortened ND = nephric duct failing to extend bilaterally (B) or unilaterally (U) to or beyond the normal ureteric budding site; ND on BW = shortened ND that veered laterally to terminate into the body wall instead of extending caudally towards the cloaca; No ND = no visible caudal extension of ND beyond the anterior mesonephric tubules; Accessory UB = smaller, duplicated ureteric bud; Separate, “floating” UB = a discontinuous, ureteric bud associated with shortened ND; No UB = lack of visible ureteric buds.
# affected/total # of embryos.
A TgH3 embryo.