Table 3.
Kidney and ureter phenotypes in e13.5 to e16.5 Gata3+/z, Gata3z/z:Tg and Gata3z/z embryos
| Genotype | Full rescue | Double ureter | Unilateral kidney | Hypoplastic kidney | Double kidney | ND on BW | Anephric |
|---|---|---|---|---|---|---|---|
| TgHi:Gata3z/z | 5/5* | 1/5 | |||||
| TgInt:Gata3z/z | 2/9 | 6/9 | 7/9 | 1/9 | 2/9 | 1/9 | |
| TgLo:Gata3z/z | 3/3 | 3/3 | |||||
| Gata3z/z | 6/16 | 16/16 |
TgHi, H14; TgInt, G6 and H12; TgLo, B6. Full rescue = complete restoration of normal sized bilateral kidneys, ureters, and normally positioned gonads; Double ureter = unilaterally duplicated ureter; Unilateral kidney = unilateral renal agenesis; Hypoplastic kidney = abnormally smaller kidney; Double kidney = unilateral renal duplication; ND on BW = nephric duct remnant terminating on body wall; Anephric = lack of kidneys.
# affected/total # of embryos.