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. Author manuscript; available in PMC: 2008 Apr 1.
Published in final edited form as: Nat Neurosci. 2007 Mar 11;10(4):469–477. doi: 10.1038/nn1868

Figure 5.

Figure 5

THP increases excitability of hippocampal pyramidal cells at the onset of puberty. (a) Current-voltage plots, The difference current recorded before and after bath application of 120 μM gabazine (pipet solution, cesium-methanesulfonate; bath contains 1 μM TTX, 1 μM GABA and 50 μM L-655,708). (b) Averaged slope conductance (gSlope, assessed from −60 to −40 mV; n = 5 – 6 cells for each group). *P < 0.05 versus pre-THP, **P < 0.05 versus Pre-pub. (c) Tight-seal cell-attached voltage-clamp recordings from the soma (−40 mV) of CA1 hippocampal pyramidal cells31. (d) THP effects on spiking, averaged data. (n = 5 cells for each group). *P < 0.05 versus Pre-THP; **P < 0.05 versus Prepub for all graphs.