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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Bioorg Med Chem Lett. 2006 Dec 12;17(5):1206–1210. doi: 10.1016/j.bmcl.2006.12.024

Table 2.

Asymmetric (R2 is DAP) headpiece substitutions.

Compda R1 R3 IC50 Ecb Sac
19 H 8 16 4 nd
12 graphic file with name nihms19148t8.jpg 8 10 1 2
20 9 7 2 16
21 10 3 4 8
22 graphic file with name nihms19148t9.jpg 8 10 4 8
23 9 18 16 32
24 10 1 16 8
25 graphic file with name nihms19148t10.jpg 8 8 2 8
26 graphic file with name nihms19148t11.jpg 8 8 2 4
27 9 11 8 16
28 10 1 16 8
29 graphic file with name nihms19148t12.jpg 8 10 4 2
30 9 12 8 32
31 10 13 32 2
32 graphic file with name nihms19148t13.jpg 8 19 4 8
33 9 13 16 32
34 10 15 16 8
35 graphic file with name nihms19148t14.jpg 8 10 8 16
36 9 19 16 32
37 10 21 16 8
38 graphic file with name nihms19148t15.jpg 8 17 2 8
39 9 40 8 64
40 10 17 16 16
41 graphic file with name nihms19148t16.jpg 8 310 16 16
42 9 40 64 32
43 10 44 16 8
44 graphic file with name nihms19148t17.jpg 8 21 4 16
45 9 31 32 32
46 10 27 32 16
47 graphic file with name nihms19148t18.jpg 8 72 16 32
48 9 77 32 64
49 10 43 32 32
50 graphic file with name nihms19148t19.jpg 9 58 16 16
51 10 36 32 16
52 graphic file with name nihms19148t20.jpg 9 14 8 nd
53 10 11 16 16
54 graphic file with name nihms19148t21.jpg 9 >1000 nd nd
55 10 >1000 nd nd
Cm 1.5 4 8

nd, not determined.

a

Cm, chloramphenicol.

b

E. coli ATCC 25922 minimum inhibitory concentration (μg/mL)4

c

S. aureus ATCC 25923 (MIC).