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. Author manuscript; available in PMC: 2008 Mar 23.
Published in final edited form as: Mol Cell. 2007 Mar 23;25(6):839–850. doi: 10.1016/j.molcel.2007.02.003

Figure 7. A concerted pathway of Cdk1/cyclin B assembly and activation.

Figure 7

Cdk1 activation is a concerted reaction in vivo, with formation of a stable Cdk1/cyclin B complex occurring simultaneously with T-loop phosphorylation by Cdk7, as suggested by the interdependence of the two steps in vitro and in vivo. This pathway, if uncoupled from inhibitory mechanisms, would not generate an unphosphorylated Cdk1/cyclin B complex as an inactive intermediate.