TABLE I.
Microdialysis studies of amphetamine-stimulated DA release in amphetamine-sensitized rats
| Amphetamine treatment | Withdrawal (days) | Challenge (mgkg) | Effect | Reference |
|---|---|---|---|---|
| Escalatine, 1 → 10 mdke 2/d × 6 weekl,d-AMP | 30-60 | 1.5 | ↑ (Acc&Cau) | Robinson, 1991 |
| Escalating, 1→ 10 mgkg 2/d → 6 weeks, d-AMP | 28 | 0.5 | ↑ (Acc & Cau) | Present study |
| Escalating, 1 → 10 mgkg 2/d ×6 weeks, d-AMP | 15-2 1 | 2.0 | ↑ (Acc) | Robinson et al., 1988 |
| 5/mgkg 2/d → 5d, d-AMP | 15 | 0.5 | ↑(Cau) | Patrick et al., 1991 |
| 2.5 μg × 3 (intra-acc d-AMP) | 14 | 1.0 (i.p.) | ↑(Acc) | Vezina, 1993 |
| 1 mgkg l/d × 10d, d-AMP | 10-14 | 0.5 | ↑ (Acc) | Wolf et al., 1993 |
| 4 mgkg l/d × 14d, meth-AMP | 7 | 4.0 | ↑(Cau) | Kazahaya et al., 1989 |
| Escalating, 1 → 10 mgkg 2/d × 6 weeks, d-AMP | 7 | 0.5 | --(Acc & Cau) | Present study |
| 2.5-3.0 mgkg l/d × 4-6d, d-AMP | 2-6 | 2.5 | ↓ (Acc & Cau) | Segal and Kuczenski, 1992 |
| 1 mgkg l/d × 10d, d-AMP | 3-4 | 0.5 | --(Act) | Wolf et al., 1993 |
| Escalating, 1 → 10 mgkg 2/d × 6 weeks, d-AMP | 3 | 0.5 | --(ACC & Cau) | Present study |