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Dissociation constants for dNTP (Kd) determined in pre-steady state experiments for the incorporation of T opposite A (A:T) and C opposite G (G:C) for several pol β variants.6
| A:T
|
G:C
|
|||
|---|---|---|---|---|
| Pol β variant | Kd (μM) | ΔGbind (kcal/mol) | Kd (μM) | ΔGbind (kcal/mol) |
| WT | 5.4 | −7.5 | 1.9 | −8.1 |
| R149A | 35 | −6.3 | 12 | −7.0 |
| R183A | 21 | −6.6 | 5.9 | −7.4 |
| K280A | n.a.a | n.a.a | 6 | −7.4 |
