Figure 1.

Alignment of RPB5 from M. thermoautotrophicum (GenBank accession no. O27122) with homologous proteins from the following: Archae: Methanococcus jannaschii (Q58443), Methanococcus vannielii (P41559), Pyrococcus abyssi (CAB49535), Pyrococcus horikoshii (O74019), Thermococcus celer (P31815), Archaeoglobus fulgidus (O28394), Aeropyrum pernix (Q9YAT3), Sulfolobus acidocaldarius (P115210), Thermoplasma acidophilum (Q03588), Halobacterium halobium (P15740). Eukarya: Saccharomyces cerevisiae (NP_009712), Schizosaccharomyces pombe (AF020780), Homo sapiens (CAA11843). Virus: swine fever virus (1097499). Amino acids that are identical and similar in M.t. with at least five other species are highlighted in green and yellow, respectively. The NMR-derived secondary structural elements of mtRPB5 are illustrated above the alignment by using the nomenclature referred to in the text.