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. 2006 Nov 1;103(46):17202–17207. doi: 10.1073/pnas.0604481103

Fig. 1.

Fig. 1.

Alterations in IKKα expression and in Ikkα in human SCCs. (A) IKKα expression in tissue arrays containing human grade I, II, and III SCCs (SCC I, SCC II, and SCC III) immunostained with an anti-IKKα antibody. +++, strong positive reactivity; ++, medium positive reactivity; +, weak positive reactivity. (B) IKKα staining in human skin (HS; strong staining), grade I SCC (strong staining), grade II SCC (weak staining), and grade III SCC (weak staining). Dark brown color, IKKα-positive staining. (C) Nucleotide sequences of exon 15 of Ikkα and its protein-encoding sequences. 533, 551, and 552, amino acid numbers in IKKα; }, deletions; ∗, identified mutations. (D) Detection of Ikkα mutations by using PCR with specific mutation primers. 533, 551, and 552, amino acid numbers in IKKα; W, wild-type primers; M, mutation primers; control, DNA from normal human skin.