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. 2006 Nov 1;103(46):17202–17207. doi: 10.1073/pnas.0604481103

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© 2006 by The National Academy of Sciences of the USA

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Fig. 4. — IKKα protein and mRNA levels in papillomas and carcinomas induced by treatment with DMBA/TPA and DMBA/DMBA in WT and Lori·IKKα-Tg (Tg) mice. (A and B) IKKα protein levels in WT and Tg papillomas and carcinomas. Control, normal skin; NS, nonspecific band; β-Tubulin, loading controls; PDC, poorly differentiated carcinomas. (C) IKKα mRNA levels measured by RT-PCR. HA-IKKα, transgenic IKKα; GAPDH, loading control. (D and E) IKKα mRNA levels in papillomas and carcinomas detected by Northern blotting. Control, normal skin; Tg, transgene; Ca, carcinoma; Pa, papilloma; 28S and 18S, RNA loading controls; CL, Ikkα^−/− immortalized cell line; ∗, poorly differentiated carcinomas.