Fig. 4.

Calculated desolvation energies mapped onto the monomeric surface representations for each of the seven human isoforms. All views look down onto the dimerization interface (Left), central binding groove, and the αG–αI helices (Right). The desolvation energies are color coded from high (blue) to low (red). The sequence conservation is mapped onto a tube representation of the τ isoform, color coded from green (100%) to white. The variable CD and HI loops are labeled V1 and V2, respectively, and the two conserved low-energy desolvation sites are labeled S1 (S1a and S1b) and S2, respectively.