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cDCs use both TLR2 and TLR9 to recognize the HSVTLR2* variants. BM DCs from WT or the indicated knockout mice were cultured with 2 MOI of UV-inactivated (A and D), live HSVTLR2* or HSVTLR2° (B and E), or known TLR agonists (C and F) for 24 h. Supernatants were analyzed for IL-6 (A–C) and IL-12 p40 (D–F) by ELISA. N/D, not detected. ∗, P < 0.05; ∗∗. P < 0.01. The data are representative of five similar experiments.
