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. 2006 Nov 1;103(46):17456–17461. doi: 10.1073/pnas.0606234103

Fig. 3.

Fig. 3.

Quantitative real-time PCR analysis of mRNA levels in the RPE–choroid of 402YY vs. 402HH donors. CRP (Left) transcript levels in the RPE–choroid of 402YY and 402HH homozygotes are not significantly greater than background (>6,000-fold lower than CRP transcript levels detected in liver; n/d, not detectable). No significant differences in CFH transcript levels are detected between 402YY and 402HH donors (Center; P = 0.15) and transcript levels in the RPE–choroid are similar to those detected in liver. When donors are segregated into AMD vs. non-AMD (irrespective of CFH Y402H genotype), no significant differences in transcript abundance are detected (Right; P = 0.16). Histograms represent the averages of normalized data from five 402YY donors, four 402HH donors, five AMD donors, and four non-AMD donors.