Fig. 2.

GCV treatment impairs contextual but not cued fear conditioning in GFAP-TK TG mice. (A) Conditioned freezing during the tone test. Percent of time freezing during the 60 s before tone presentation (pretone) and during the 20-s tone presentation (tone) is shown. Data were subjected to a 2 (treatment) × 2 (period: pretone vs. tone) ANOVA [n = 19 (WT) and 11 (TG)]. Mice froze significantly more during the tone than during the pretone period [F(1,28) = 14.1, P < 0.001]. There was no effect of genotype [F(1,28) = 0.5] or genotype × period interaction [F(1,28) < 1]. (B) Percent time freezing during the 4 min of the context test. Data were subjected to a 2 (treatment) × 4 (minute) ANOVA. Irradiated mice spent significantly less time freezing than did sham mice [F(1,28) = 4.7, P = 0.04].