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. 2006 Nov 6;103(46):17501–17506. doi: 10.1073/pnas.0607207103

Fig. 3.

Fig. 3.

Ablation of neurogenesis prevents a form of LTP in the DG. Slices for physiological experiments were derived either 3 months after x-ray treatment (A-C) or immediately after a 6-week GCV treatment was completed (D-F). (A) MPP/DG LTP in sham (n = 8) and irradiated (n = 8) mice 3 months after treatment. Arrow indicates the delivery of the 100-Hz stimulation. Repeated-measures ANOVA performed on the last 10 min of recording confirmed a significant difference between sham and x-irradiated animals [F(1,14) = 11.2, P < 0.001]. (B) LTP evoked in the DG after the addition of 50 μM picrotoxin. Stimulation parameters are the same as above. There is no difference in LTP between sham and irradiated mice [F(1,14) < 1]. (C) LTP in the Schaffer collateral to CA1 connection was not altered by irradiation [F(1,14) < 1]. (D) Six weeks of GCV treatment caused a loss of LTP in the DG in TG (n = 9) but not WT (n = 15) mice. Repeated measures ANOVA on the last 10 min confirmed a significant difference between WT and TG animals [F(1,24) = 7.2, P = 0.01]. (E) GCV treatment did not alter DG LTP elicited in the presence of 50 μM picrotoxin [F(1,24) < 1]. (F) LTP in Schaffer collateral/CA1 connections was also unaffected by GCV [F(1,24) < 1]. Error bars represent ± 1 SEM.