Table 2.
Effect of food composition on the pharmacokinetics of TU, DHTU, testosterone and DHT after single oral administration of 80 mg TU
| Parameter (units) | Meal A | Meal B | Meal C | Meal D |
|---|---|---|---|---|
| TU | ||||
| Cmax (nmol/l) | 20·2 (181) | 47·8 (124) | 372 (84·5) | 382 (87·7) |
| tmax (h) | 5·0 (2·0–11·0) | 5·0 (2·0–7·0) | 5·0 (2·0–7·0) | 5·0 (2·0–12·0) |
| AUC0–tlast (nmol h/l) | 41·7 (176) | 103 (149) | 848 (53·3) | 1050 (46·7) |
| DHTU | ||||
| Cmax (nmol/l) | 10·4 (160) | 22·2 (91·0) | 150 (53·7) | 174 (56·2) |
| tmax (h) | 5·0 (3·0–12·0) | 5·0 (4·0–8·0) | 5·0 (2·0–8·0) | 6·0 (2·0–12·0) |
| AUC0–tlast (nmol h/l) | 27·1 (192) | 66·8 (116) | 479 (39·9) | 677 (34·7) |
| Testosterone | ||||
| Cmax (nmol/l) | 4·65 (80·8) | 7·10 (70·0) | 27·3 (44·7) | 27·0 (51·6) |
| tmax (h) | 3·0 (1·0–11·0) | 5·0 (1·0–8·0) | 5·0 (2·0–7·0) | 6·0 (2·0–12·0) |
| AUC0–tlast (nmol h/l) | 30·7 (59·9) | 43·5 (48·2) | 146 (30·6) | 154 (32·2) |
| DHT | ||||
| Cmax (nmol/l) | 1·50 (65·8) | 1·89 (53·7) | 6·67 (45·7) | 6·74 (49·3) |
| tmax (h) | 3·0 (1·0–12·0) | 6·0 (1·0–10·0) | 7·0 (3·0–9·0) | 7·0 (4·0–14·0) |
| AUC0–tlast (nmol h/l) | 7·62 (78·9) | 11·0 (73·8) | 49·5 (42·0) | 57·9 (38·7) |
Presented are geometric means (geometric CV%), except for tmax: median (min − max).
n = 24 except for treatment type A, where n = 22 for TU and DHT and n = 23 for DHTU.