A,B Schematic representation of the re-sequenced human FSHB region. a Gene structure drawn to an approximate scale. Exons (E1-E3) are indicated by boxes with the coding and non-coding sequences denoted by grey and open areas, respectively. E1 contains an alternate splice donor site resulting in two forms, A and B; E3 contains alternate polyadenylation sites, A and B (Jameson et al. 1988). The intron processing and polyadenylation are regulated independently. b Human SNPs (vertical black bars) identified in Estonians, Mandenkalu and Han are marked as long bars for common SNPs (MAF >10%) and short bars for rare SNPs (<10%). The SNP positions are relative to ATG. Five tag-SNPs (dotted ellipses) were chosen for genotyping the Korean, Czech, CEPH and STP-sample. Two of the tag-SNPs (rs594982 and rs6169) also represent RFLPs.