Table 6.4 Placebo controlled trials of antibiotics for maintenance of medically induced remission in Crohn's disease.
| Author | Year | Number of patients | Antibiotics | Duration (months) | Relapse rate (%) | Combined treatments | Ref section 2 | ||
|---|---|---|---|---|---|---|---|---|---|
| Antibiotics | Placebo | p Value | |||||||
| Elliott | 1982 | 51 | Sulfadoxine + pyrimethamine | 12 | 62 | 50 | No | 131 | |
| Shaffer | 1984 | 27 | Ethambutol + rifampicine | 24 | 64 | 36 | NS | Corticosteroids Sulfasalazine | 132 |
| Basilisco | 1989 | 24 | Rifabutine | 6 | 71 | 62 | Miscallenaous | 133 | |
| Afdhal | 1991 | 49 | Clofazimine | 12 | 36 | 50 | Corticosteroids | 134 | |
| Prantera | 1994 | 40 | Ethambutol + clofazimine + dapsone + rifampicine | 9 | 89 | 41 | 0.03 | Corticosteroids | 135 |
| Swift | 1994 | 126 | Ethambutol + rifampicine + isoniazide | 24 | 65 | 62 | NS | Corticosteroids esalazine | 136 |
| Goodgame | 2001 | 31 | Clarithromycine + ethambutol (3 months) | 12 | ‐ | ‐ | NS | No | 137 |