Table 6.5 Placebo controlled trials of azathioprine for maintenance of medically induced remission in Crohn's disease.
| Author | Year | Number of patients | Dose(mg/kg/day) | Duration (months) | Relapse rate (%) | Ref section 2 | ||
|---|---|---|---|---|---|---|---|---|
| Azathioprine | Placebo | p Value | ||||||
| Willoughby | 1971 | 10 | 2 | 6 | 20 | 60 | <0.05 | 139 |
| Rosenberg | 1975 | 20 | 2 | 9 | 20 | 50 | <0.01 | 140 |
| O'Donoghue | 1978 | 51 | 2 | 12 | 5 | 41 | <0.05 | 141 |
| Summers (NCCDS) (1st part) | 1979 | 19 | 2.5 | 9 | 16 | 25 | NS | 96 |
| Summers (NCCDS) (2nd part) | 1974 | 54 | 1 | 24 | – | – | NS | |
| Candy | 1995 | 43 | 2.5 | 12 | 58 | 93 | <0.001 | 142 |
| Lémann (GETAID) | 2002 | 83* | 1.7 | 18 | 8 | 21 | NS (non‐inferiority design) | 69, 143 |
*Remission while receiving azathioprine >42 months.