Table 3 Association of cathepsin B gene polymorphisms in tropical calcific pancreatitis patients and controls.

SNP†	Cohort I						Cohort II						Total
	Allele frequency‡		χ2	OR	95% CI	p Value	Allele frequency‡		χ2	OR	95% CI	p Value	Allele frequency‡		χ2	OR	95% CI	p Value
	Patients (n = 140)	Controls (n = 155)					Patients (n = 166)	Controls (n = 175)					Patients (n = 306)	Controls (n = 330)
Leu26Val*	0.48	0.30	6.81	2.15	1.60–2.90	0.009	0.45	0.28	6.23	2.10	1.56–2.84	0.013	0.46	0.29	6.17	2.09	1.55–2.81	0.013
C595T	0.12	0.20	2.38	0.55	0.37–0.81	0.123	0.10	0.21	4.62	0.41	0.28–0.63	0.032	0.11	0.21	3.72	0.46	0.31–0.70	0.054
T663C	0.52	0.58	0.73	0.78	0.59–1.04	0.394	0.53	0.60	1.00	0.75	0.56–1.00	0.318	0.53	0.59	0.73	0.78	0.59–1.04	0.393
Ser53Gly	0.10	0.04	2.76	2.67	1.45–4.91	0.096	0.09	0.04	2.06	2.37	1.28–4.40	0.152	0.09	0.04	2.06	2.37	1.28–4.40	0.152

n, number of individuals, χ², chi square value; OR, odds ratio; 95% CI, 95% confidence interval; SNP, single nucleotide polymorphism.

†Nomenclature is represented as wild status‐position‐mutant status.

‡, mutant allele frequency.

The frequency of mutant alleles for each SNP was compared between patients and controls and Pearson's χ² and p values were calculated together with OR and 95% CI.

*Statistically significant after allowing for multiple post hoc testing (p_corr  = 0.025, with Bonferroni correction).