Table 2.
Summary of the small-effect QTL identified in this study
| Loci | Chromosome | Peak marker | Position (Mb) | P value | Susceptibility allele | Overlapping QTL in mouse models of RA | Snyternic region linked to RA (linked marker) |
| 1a,b,c | 5 | D5Mit348 | 23,9 | 0.00691 | DBA/1 | Cia13 | |
| 2b | 5 | D5Mit425 | 119,1 | 0.04397 | DBA/1 | Cia14 | 22q11 (D22S264), 12p13-q24 (D12S95) |
| 3a,b,c | 6 | D6Mit14 | 145,7 | 0.00315 | FVB/N | 12p13-pter (D12S99) | |
| 4a,b,c | 7 | D7Mit248 | 59,3 | 0.03250 | DBA/1 | ||
| 5a,c | 10 | D10Mit261 | 85,1 | 0.00647 | DBA/1 | Cia8 | 21q22-qter (D21S268), 10q22-23 (D10S2327) |
| 6b,c | 11 | D11Mit214 | 115,2 | 0.00521 | DBA/1 | Pgia7 | 17q21-q25 (D17S1301) |
| 7c | 16 | D16Mit138 | 45,4 | 0.01499 | FVB/N | 3q29-qter (D3S1311) | |
| 8c | 17 | D17Mit197 | 18,3 | 0.02994 | FVB/N |
aIdentified in all F2 290 progeny. bIdentified in 76 C5+/+ F2 progeny. cIdentified in 133 C5+/- F2 progeny. QTL, quantitative trait loci; RA, rheumatoid arthritis.