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. 2007 Jan 25;9(1):R6. doi: 10.1186/ar2112

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Copyright © 2007 Segond von Banchet et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Influence of soluble mediators on the expression of neurokinin 1 (NK1), bradykinin 2 (B2), and transient receptor potential V1 (TRPV1) receptors in dorsal root ganglion (DRG) neurones. Proportion of DRG neurones with (a) NK1 receptor-like immunoreactivity (IR), (b) B2 receptor-like labelling, and (c) TRPV1 receptor-like immunoreactivity after culturing either in normal medium, or after administration of the supernatant of fibroblast-like synovial (FLS) cells from normal, acutely or chronically inflamed knee joints. ^#Significant difference to DRG mono-cultures. ^$Significant difference to co-culture with FLS cells from normal knee joints. AIA, antigen-induced arthritis.