Table A3 Association of non‐invasive markers with fibrosis stage in non‐alcoholic fatty liver disease.
| F0/1/2 v F3/F4 | Age (increased) | Diabetes (present) | BMI (increased) | AST/ALT ratio (increased) | HOMA‐IR (increased) | Platelets (decreased) | HA (increased) | Miscellaneous (association with fibrosis) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Angulo (1999)11 | Yes UVA and MVA | Yes UVA and MVA | Yes UVA | Yes UVA and MVA | Not tested | Not tested | Not tested | Obesity at UVA and MVA. ALT, transferrin saturation, and albumin at UVA | ||||||||
| Rosenberg12 | Yes UVA, MVA, and ROC | Not tested | Not tested | Not tested | Not tested | Not tested | Yes UVA, MVA, and ROC | PIIINP and TIMP1 also included in discriminant score | ||||||||
| Sakugawa13 | Yes UVA | No** | No | Yes UVA | No | Yes UVA | Yes UVA, MVA and ROC | Female, platelets GGT and albumin on UVA. Type IV collagen at UVA, MVA and ROC. | ||||||||
| Albano14 | Yes UVA | Yes UVA and MVA | No | Yes UVA and MVA | Not tested | Not tested | Not tested | MDA abs UVA and MVA | ||||||||
| Mofrad15 | No | Yes UVA and MVA | No | Not tested | Not tested | Not tested | Not tested | |||||||||
| Shimada16 | Yes UVA and MVA | Yes UVA | No | Yes UVA and MVA | Not tested | Yes UVA and MVA | Yes UVA and MVA | Albumin, bilirubin, ferritin, IgA, hyperlipidaemia, type IV collagen and IgA on UVA. Platelet count on UVA/MVA. | ||||||||
| Dixon17 | No | Yes UVA | No | No | Yes UVA | Not tested | Not tested | Hypertension, raised C peptide and ALT by MVA | ||||||||
| Beymer18 | No | Yes MVA | No | Not tested | Not tested | Not tested | Not tested | |||||||||
| Bugianesi19 | Yes UVA | Yes (fasting glucose) UVA | Yes UVA | Yes UVA | Yes UVA | Not tested | Not tested | Female sex, 100/ISI, I/QUICKI, ferritin, OGIS at UVA | ||||||||
| Dixon (2003)20 | Yes UVA | Not tested | Yes UVA | No | Yes UVA and MVA | Not tested | Not tested | Raised ALT and combination of high risk phenotypes of polymorphisms (TGF‐β and AT) on UVA and MVA | ||||||||
| Hui21 | Yes UVA | Not tested | Not tested | Not tested | Yes UVA and MVA | Not tested | Not tested | |||||||||
| Guidorizzi de Siqueira22 | Not tested | Not tested | Not tested | Not tested | Yes UVA | Not tested | Not tested | |||||||||
| Suzuki23 | Yes UVA | Yes (fasting glucose) UVA and ROC (clinical diagnostic model) | No | Yes ROC (clinical diagnostic model) | Not tested | Yes UVA | Yes UVA and MVA. | Serum albumin and platelet count at UVA. Ferritin, clinical diagnostic model (age, diabetes, AST/ALT, obesity) at ROC. | ||||||||
| Angulo24 | Yes UVA and MVA | Yes UVA | Yes UVA | Not tested | Yes UVA | Not tested | Not tested | Leptin and female at UVA QUICKI at UVA and MVA | ||||||||
| Marchesini25 | Not tested | Not tested | Not tested | Not tested | Not tested | Not tested | Not tested | Metabolic syndrome by MVA | ||||||||
| Hashimoto26 | Yes UVA | Yes UVA | No | Yes UVA | Not tested | Yes UVA | Yes UVA and MVA | Sex, hypertension, platelet count, albumin, type IV collagen at UVA. Billirubin at MVA. | ||||||||
| Ong27 | No | Yes UVA and MVA | No | No | Not tested | Not tested | Not tested | Raised AST, ALT and WHR on MVA. | ||||||||
| Ledinghen28 | No | Not tested | Yes (BMI>25) UVA | Yes (Raised ALT) UVA | Not tested | No | Not tested | Ferritin at UVA | ||||||||
| Ratziu29 | Yes UVA and MVA | Yes UVA | Yes (BMI>28) UVA and MVA | No | Not tested | Not tested | Not tested | BAAT score (BMI, age, ALT, TGs) by MVA and ROC | ||||||||
| Sorrentino30 | No | Yes (with metabolic syndrome) MVA | Yes BMI>45 MVA | Not tested | Not tested | Not tested | Not tested | Female sex and duration of obesity MVA | ||||||||
| Crespo31 | Yes UVA and MVA | No | No | Not tested | Not tested | Not tested | Not tested | Raised blood glucose at UVA | ||||||||
| Fierbinteanu‐ Braticevici 32 | Yes UVA and MVA | Not tested | Yes UVA and MVA | Not tested | Not tested | Not tested | Not tested | Raised ALT, ferritin, MDA, GSH and TGs at UVA and MVA. No stats on score. | ||||||||
| Loguercio33 | No | Not tested | No | Not tested | Yes UVA | Not tested | Not tested | Ferritin at UVA | ||||||||
| dos Santos34 | No | Not tested | No | No | Not tested | Not tested | Yes UVA | Laminin, AST and collagen IV UVA | ||||||||
| Yesilova35 | Not tested | No | No | Not tested | Yes Positive correlation | Not tested | Not tested | CoQ10 and CuZnSOD negative correlation | ||||||||
| Koruk36 | Not tested | Not tested | Not tested | Not tested | Not tested | Not tested | Not tested | Raised TGs, LDL shoed positive correlation and Apo A1showed negative correlation | ||||||||
| Hartleb37 | Yes UVA | Yes UVA | Yes UVA | Not tested | Not tested | Not tested | Not tested | HT at UVA | ||||||||
| Chitturi38 | No | No | No | Not tested | Not tested | Not tested | Not tested | |||||||||
| Brunt39 | No | No | No | Yes UVA | No | Not tested | Not tested | Serum albumin reduced in severe disease | ||||||||
Yes, association at univariate analysis, correlation or multivariate analysis, p<0.05.
No, no association at univariate or multivariate analysis.
UVA, univariate analysis; MVA, multivariate analysis; BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; HOMA‐IR, homeostatic insulin resistance; MDA, malondialdehyde; TG, triglycerides; TIMP‐1, tissue inhibitor of metalloproteinase; PIIINP, aminoterminal peptide of procollagen III; TGF‐β, transforming growth factor β; GGT, gamma glutamyl transferase; QUICKI, quantitiative insulin sensitivity check index; OGIS, oral glucose sensitivity index; GSH, glutathione; CoQ10, coenzyme Q10; Cu ZnSOD, copper zinc oxide dismutase; LDL, low density lipoprotein; Apo A1, apoprotein A1; ROC, receiver operating characteristic curve.