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Chemical structure and EC50 values (nM) of closely related retinoids describing their transcriptional activation properties
BMS189961 is a racemic mixture of BMS270394 (Kd = 500 nM) and BMS270395 (no binding); the activity resides only in the former. The other ligands show the role of the hydroxyl group and the fluorine atom to generate a RARγ-selective retinoid.
