Table 2 Comparison of clinicopathological factors for patients with K‐ras mutation negative and positive margins.
| Clinicopathological factor | K‐ras mutation in margin | *p Value | |
|---|---|---|---|
| Negative (n = 33) | Positive (n = 37) | ||
| Age (y) | 0.075 | ||
| Mean (SD) | 65 (9) | 69 (11) | |
| Sex | 1.0 | ||
| Female | 17 (52%) | 18 (49%) | |
| Male | 16 (48%) | 19 (51%) | |
| UICC/TNM stage† | 0.33 | ||
| pI‡ | 10 (30%) | 16 (43%) | |
| pII‡ | 23 (70%) | 21 (57%) | |
| Primary tumour | 0.17 | ||
| T1 | 11 (33%) | 5 (14%) | |
| T2 | 19 (58%) | 27 (72%) | |
| T3 | 3 (9%) | 5 (14%) | |
| Lymph node metastasis | 0.15 | ||
| N0 | 11 (33%) | 19 (51%) | |
| N1 | 22 (67%) | 18 (49%) | |
| Tumour size (cm) | 0.20 | ||
| 0–2 | 12 (36%) | 8 (22%) | |
| >2 | 21 (64%) | 29 (78%) | |
| Pathological grade | 0.037 | ||
| Well | 3 (9%) | 8 (22%) | |
| Moderate | 21 (64%) | 12 (32%) | |
| Poor | 9 (27%) | 17 (46%) | |
| Perineural invasion | 0.024 | ||
| Absent | 16 (48%) | 8 (22%) | |
| Present | 17 (52%) | 29 (78%) | |
| Lymphovascular invasion | 0.027 | ||
| Absent | 29 (88%) | 23 (62%) | |
| Present | 4 (12%) | 14 (38%) | |
| PanIN in margin¶ | 1.0 | ||
| Absent | 1 (7%) | 2 (12.5%) | |
| Present | 13 (93%) | 14 (87.5% | |
| 1 | 9 | 8 | |
| 2–3 | 4 | 6 | |
| K‐ras mutation in tumour | 0.36 | ||
| Absent | 8 | 25 | |
| Present | 5 | 32 | |
*Comparison for age was performed by the Student's t test; the remaining clinical factors were compared by Fisher's exact test.
†UICC/TNM 6th edition.
‡pI and pII, pathological stage I and pathological stage II.
¶For patients with available pancreatic intraepithelial neoplasia data.