Table 2 Histological assessment of fibrosis and inflammation in control (CTR) and bile duct ligated (BDL) rats given naltrexone or saline.
| CTR | BDL | |||
|---|---|---|---|---|
| Saline (n = 8) | Naltrexone (n = 8) | Saline (n = 12) | Naltrexone (n = 12) | |
| Fibrosis | ||||
| Stage 0 | 8 | 8 | 0 | 4 |
| Stage 1 | 0 | 0 | 2 | 6 |
| Stage 2 | 0 | 0 | 4 | 2 |
| Stage 3 | 0 | 0 | 6 | 0 |
| Stage 4 | 0 | 0 | 0 | 0 |
| Mean (SEM) | 0.00 (0.00) | 0.00 (0.00) | 2.33 (0.22)* | 0.83 (0.20)*† |
| Inflammation | ||||
| Score 0 | 8 | 8 | 0 | 2 |
| Score 1 | 0 | 0 | 8 | 6 |
| Score 2 | 0 | 0 | 2 | 3 |
| Score 3 | 0 | 0 | 2 | 1 |
| Score 4 | 0 | 0 | 0 | 0 |
| Inflammatory score | ||||
| Mean (SEM) | 0.00 (0.09) | 0.00 (0.00) | 1.50 (0.23)* | 1.25 (0.25)* |
*p<0.05 compared with control groups; †p<0.05 compared with BDL/saline group.