Table 1 Reported cases of exacerbation of ulcerative colitis induced by interferon (IFN) therapy in Japana Centra Revuo Medicina (in Japan) and in MEDLINE.
| Author, year, country | Age/ sex | Background | IFN | Period to exacerbation | Region of colitis | Therapy | Result |
|---|---|---|---|---|---|---|---|
| Mitoro 1993 Japan1 | 34M | Hepatitis C | IFN‐α | 23 days | R‐A | Conservative | Reinjection of IFN under administration of SASP |
| Honda 1993 Japan2 | 50M | Hepatitis C | IFN‐α | 14 months | R‐D | SASP | Exacerbation after readministration of IFN |
| Yasumori 1995 Japan3 | 42M | Hepatitis B | IFN‐α | 1 day | Total colon | Total colectomy | Death |
| Yamamoto 1995 Japan4 | 40M | Hepatitis C | IFN‐α | 5 months | R‐S | SASP | Discontinuation of IFN |
| Usami 1999 Japan5 | 47M | Renal cancer | IFN‐α,γ | 12 months | R‐A | Conservative | Discontinuation of IFN |
| Mavrogianni 2001 Greece8 | 29F | Hepatitis C | IFN‐α | 14 days | R | Mesalazine+steroid | Continuation of IFN under administration of mesalazine and steroid resulted in exacerbation of UC |
| Niki T 2001 Japan6 | 49M | Hepatitis C | IFN‐α | 2 months | Total colon | Mesalazine, steroid | Discontinuation of IFN |
| Awakawa 2002 Japan7 | 48M | Hepatitis C | IFN‐β | 7 days | R‐A | Mesalazine | Discontinuation of IFN |
| Sprenger 2005 Austria9 | 54M | Hepatitis C | PEG‐IFN‐α + ribavirin | 3.5 months | Total colon | Mesalazine+steroid | Discontinuation of PEG‐IFN‐α and ribavirin |
| Watanabe (2006) Japan (present study) | 55M | Hepatitis C | PEG‐IFN‐α + ribavirin | 2.5 months | R‐D | Mesalazine+steroid | Discontinuation of PEG‐IFN‐α and ribavirin |
R, rectum; S, sigmoid colon; D, descending colon; A, ascending colon; SASP, salazosulfapyridine; UC, ulcerative colitis.